In our study, there was a similar disease constitution in cohort B (200 HCC patients and 97 liver diseases control),and the results showed that the combination of DCP and AFP had a total specificity of 93.81%, which was higher than that of either DCP (90.72%) or AFP (69.07%) alone, whereas the sensitivity of DCP (82.63%) alone was higher than that of either the combination of DCP and AFP (78.5%) or AFP (62%) alone (Table 1). This evidence concerns the gene ACE and hepatocellular carcinoma.