Although the positive rate of DCP in AFP-positive HCC was higher than that in AFP-negative HCC [A: 85.6% vs. 76·3%; B: 91.1% vs. 63.2%, Fig 2C and 2D, S2A and S2B Fig], there was no correlation between AFP and DCP because the correlation indices (R2 values) were only 0.061 in cohort A and 0.163 in cohort B (S2C and S2D Fig). The gene discussed is AFP; the disease is hepatocellular carcinoma.