In mouse epidermal cells, cocoa polyphenols inhibited TNF-α-induced phosphorylation of protein kinase B (PKB/AKT) and extracellular-regulated kinases (ERK) and suppressed the TNF-α-induced mitogen activated protein kinase-1 (MEK1) activity and the phosphatidylinositol-3-kinase (PI3K) activity, suggesting a chemopreventive potential against pro-inflammatory cytokine-mediated skin cancer and inflammation [45]. This evidence concerns the gene AKT1 and skin neoplasm.