MPO and colitis: Finally, and as mentioned above, neutrophil infiltration can be considered one of the main pathological features of human IBD [66], and most active flavonoids assayed in experimental colitis models significantly reduced neutrophil infiltration into the damaged colonic tissue, as evidenced by a significant reduction of colonic myeloperoxidase [40,50,55,56,57,60,61,68,69,70], thus contributing to the amelioration of the intestinal inflammation.