Among these, chemically induced models (acetic acid, trinitrobenzenesulfonic acid (TNBS) or dextran sulphate sodium (DSS)), genetically engineered mice (HLA-B27 rats or IL-10 knock-out (KO) mice), and a T cell–transfer model have been used broadly and have been shown to share some similarities with human IBD [35]. Here, IL10 is linked to inflammatory bowel disease.