Therefore, the purpose of the present study was to detect the association of six SNPs (rs7395662, rs326214, rs326217, rs1051006, rs3736101, and rs7120118) in or near MADD-FOLH1 and their haplotypes with serum lipid traits and the risk of CHD and IS in a Chinese Han populations. This evidence concerns the gene FOLH1 and coronary artery disorder.