Nonetheless, a combination gene transfer of h.FVIII and miR-15b was attempted as an improvement in local hemostasis and miR-15b/VEGF-α reconstitution is desirable in the setting of a bleeding disorder like hemophilia A. Interestingly, miR-15b has potential binding targets in VEGF-α and is known to downregulate expression of this proangiogenic factor [14,15,21]. Here, F8 is linked to hemorrhagic disease.