EPAS1 and arthropathy: While the role of miRs (miR-214, miR-126) is known to contribute to endothelial diseases [36], the multifactorial etiology of hemophilic arthropathy is likely to involve other miRs) that further regulate the target molecules involved in arthropathy (VEGF-α, HIF-2α and MMP 3 and MMP 9).