In particular, the coordinated activation of miRNAs (e.g., miR-21, miR-302 and miR-10b) and various signaling regulators by HA-CD44 interaction as illustrated in three models (Figure 3, Figure 4 and Figure 5) could contribute to a variety of tumor cell-specific behaviors, tumor metastasis, progression and chemoresistance. Here, CD44 is linked to neoplasm.