Knockdown of Pthlh (Figure 2—figure supplement 1D) reduced the proliferation (Figure 2—figure supplement 1E), transcription of known target genes (Figure 2—figure supplement 1F–G) and the levels of pCREB1, and surprisingly, total CREB1 in OS cells at early time points post infection (Figure 2F). The gene discussed is CREB1; the disease is infection.