PET-based imaging of TSPO offers a unique opportunity to probe for this marker of activated glial cells (microglia, astrocytes) in vivo, based on the increased expression of TSPO by activated glia in states of brain injury or repair.14, 15, 16, 17, 18, 49 We recently showed [11C]DPA-713 PET allows us to measure increases in TSPO in other neurologic diseases associated with inflammation.26, 27. The gene discussed is TSPO; the disease is nervous system disorder.