We reported here that deliberate inhibition of selected DLK1-Dio3 miRNAs such as miR-154, miR-379, and miR-300 significantly reduced the production of lupus-associated cytokines IFNγ, IL-1β, IL-6, and/or IL-10 (Fig 6). The gene discussed is IL6; the disease is systemic lupus erythematosus.