The dysregulation of DLK1-Dio3 miRNAs was also evident in B6-lpr and NZB/WF1 lupus mice (such as miR-127 and miR-379) [28, 44], and in human lupus patients (such as miR-134, miR-379, and miR-433)[21, 29]. The gene discussed is DLK1; the disease is systemic lupus erythematosus.