DIO3 and systemic lupus erythematosus: In our previous study of profiling dysregulated miRNAs in different murine lupus models with miRNA microarray, we found that 11 out of the 17 upregulated miRNAs in splenocytes of MRL-lpr mice belong to the largest miRNA cluster located at the genomic imprinted DLK1-Dio3 region [28].