The loss of genomic imprinting (LOI) expression of DLK1-Dio3 miRNAs in acute promyelocytic leukemia (APL) and type 2 diabetes mellitus (T2DM) has been associated with altered DNA methylation at Gtl2 (MEG3)-DMR region [52, 53]. The gene discussed is DIO3; the disease is type 2 diabetes mellitus.