In conclusion, our meta-analysis indicated that the ESR1 rs3798577:T>C polymorphism might be a risk factor for BC in Asians and that the ESR1 rs3798577:T>C polymorphism and ESR1 rs2228480:A>G polymorphism had a large protective effect in Caucasians, while the ESR1 rs2077647:T>C polymorphism was not associated with BC risk. Here, ESR1 is linked to breast cancer.