Fully advanced HCCs developed 14 months after treatment with DENA displayed several clusters of hepatocytes positive for both MCT4 and TRAP1 (Figure 2D), and an increase in TRAP1 protein levels in HCC, as well as in GST-P+/KRT-19+ nodules, was confirmed by Western blot analysis (Figure 2E). The gene discussed is TRAP1; the disease is hepatocellular carcinoma.