TIGAR and cancer: Additionally, fructose-2,6-bisphosphatase TP53-inducible glycolysis and apoptosis regulator (TIGAR) which decreases the level of fructose-2,6-bisphosphate, leading to inhibition of late glycolytic steps [16] and increasing glucose funneling into the PPP, was strongly induced in GSTP+/KRT19+ preneoplastic nodules, HCCs and RH cancer cells (Figure 2A-3C and Supplementary Figure S5C), but not in normal liver or GSTP+-KRT-19− nodules.