In addition, the expression of Hexokinase II (HK II), the HK isoform highly induced in a variety of tumor cells [28], where it binds to mitochondria and contributes to cell survival [29, 30, 31], was much higher in RH cells than in RNT hepatocytes (Figure 3C), where HK II associated with mitochondria (Supplementary Figure S3B). Here, HK2 is linked to neoplasm.