The results shown in Figure 2 demonstrate that the percentage of CXCR5+CD4+ T cells was higher in Group I CVID patients when compared to those of Group II and N. Regarding Group II CVID patients, there were no significant differences when compared to N. Concerning coexpression of PD-1 and CXCR5, the highest values were observed in CVID patients with a GD and/or AI disease phenotype (Group I). This evidence concerns the gene CD4 and common variable immunodeficiency.