Bearing in mind that insulin loss is gradual in the case of WSD and that some monogenic forms of diabetes are sensitive towards insulin secretagogues, the aim of the current study was to elucidate whether exenatide, a GLP-1 receptor agonist, and glipizide, a sulphonylurea, are effective glucose-lowering agents in a mouse model of Wolfram syndrome 1. The gene discussed is INS; the disease is diabetes mellitus.