Although GAPDH is a suitable reference gene in mouse caerulein-induced acute pancreatitis [18, 19, 29, 30] and during the early phase of mouse SAP induced by caerulein and LPS, the variation in GAPDH mRNA expression should not be ignored, which probably results from glucose metabolism disturbance in the later phase of the illness [54]. This evidence concerns the gene GAPDH and acute pancreatitis.