Menon et al. (2014) found that the receptor activator of NF-kappa B ligand mediates bone resorption in IH, while Tozawa et al. (2008) reported that oxalate induced OPN expression by activating NF-kappa B in renal tubular cells. But there have been few researches focus on the function of NF-kappa B in the formation of idiopathic hypercalciuria urolithiasis. Furthermore, abnormal fat metabolism would also activate the NF-kappa B signaling pathway (Yang et al., 2015), which might contribute to the increased risk of urolithiasis in obesity populations. This evidence concerns the gene SPP1 and obesity due to melanocortin 4 receptor deficiency.