Interestingly, the sIL-7R displayed a strong association with serum anti-C1q antibodies in SLE patients, implying that both of them may be novel biomarkers in SLE, and a combination of sIL-7R and anti-C1q antibodies, or other serological biomarkers, may increase the diagnostic specificity for identification of patients with active SLE or LN. This evidence concerns the gene IL7R and lobular neoplasia.