Increased GLUT4 immunoreactivity was in compliance to Chou et al findings; They observed a significant increase in GLUT4 protein under 4 weeks hypoxia in rats cardiac muscle.24 Increased expression of GLUT4 protein in the heart may suggest elevated expression of GLUT4 in all muscles of the body.10 Another important finding of this study is that CIH as a simulation of altitude suppressed diabetes-induced hyperglycemia and elevated HOMA-IR that partially resulted from increased GLUT4 protein expression in the heart tissue cells. Here, SLC2A4 is linked to diabetes mellitus.