In this study, we investigated the mixture of LJT and RGL (JAL2, 1 : 1) and whether 30% ethanol extracts of JAL2 attenuates hyperglycemia and reduces the body weight via stimulating GI hormones such as GLP-1 and PYY, respectively, using db/db mice, which has the characteristics of T2DM. This evidence concerns the gene RGL1 and type 2 diabetes mellitus.