There are 32 overlapping genes between aspirin and active components of S. miltiorrhiza depside salt, such as JUN, VCAM-1, TGFB1, TGFB1, IL8, IL1B, NOS2, NOS3, MAPK1, MAPK8, CASP3, MMP1, and MMP2 that have been associated with the cardiovascular diseases (coronary heart disease, angina pectoris, atherosclerosis, and thrombosis which are all within the scope of CHD) as biomarkers or therapeutic targets from the Comparative Toxicogenomics Database. The gene discussed is MAPK8; the disease is atherosclerosis.