Unique pathways of active components of S. miltiorrhiza depside salt were as follows: cancers (6), immune diseases or systems (4) (autoimmune thyroid disease, primary immunodeficiency, B cell receptor signaling pathway, and Fc gamma R-mediated phagocytosis pathway), endocrine diseases or systems (4) (insulin signaling pathway, type II diabetes mellitus, adipocytokine signaling pathway, GnRH signaling pathway, and progesterone-mediated oocyte maturation), cellular processes (3) (cell cycle, regulation of autophagy, and oocyte meiosis), and mTOR signaling pathway (1). Here, GNRH1 is linked to autoimmune thyroid disease.