Unique pathways of aspirin were as follows: metabolism pathways (17) (arachidonic acid metabolism, linoleic acid metabolism, other carbohydrate metabolisms, and another 14 related pathways), immune diseases and system (4) (Huntington's disease, allograft rejection, amyotrophic lateral sclerosis (ALS) pathway, and complement and coagulation cascades pathway), human diseases (3) (viral myocarditis, Alzheimer's disease, and Parkinson's disease), PPAR signaling pathway (1), ABC transporters pathway (1), and ECM-receptor interaction pathway (1). The gene discussed is PPARA; the disease is early-onset autosomal dominant Alzheimer disease.