AKT1 and myocardial ischemia: Moreover, it has been observed that PPARα ligands, including fibrates, reduce myocardial ischemia/reperfusion (I/R) injury in diabetic and nondiabetic animals; this cardioprotection might be mediated through anti-inflammatory mechanisms and via the activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt)/NO pathway [8, 14, 15].