IL16 and colorectal carcinoma: A larger case-control study (8634 cases, 8553 controls) examined the risk of CRC according to expression of two different SNPs, rs2965667 (located close to the microsomal glutathione S-transferase 1 gene, often upregulated in CRC) and rs16973225 (located close to the interleukin 16 gene, which has been implicated in CRC carcinogenesis) [20••].