Moreover, it was observed that IL-18 protein and IL-18R were strongly expressed in the lungs of fatal asthma [2], serum IL-18 levels were significantly higher in children who had asthma [3], and IL-18 variants were significantly associated with asthma severity [4], implicating that IL-18 may contribute to the development of asthma. The gene discussed is IL18; the disease is asthma.