Tregs suppress blood vessel normalization [52] but a range of inflammatory stimuli including tumour EC-targeted TNF-α [53,54], eosinophils [55], irradiation [56] and TLR ligands [57], in the presence or absence of transferred tumour specific T-cells, can overcome Treg suppression and induce vessel normalization and homing molecule expression on tumour EC. The gene discussed is TNF; the disease is neoplasm.