NR0B2 and neoplasm: NSC-87877 is a small molecule competitive inhibitor of SHP-2, which is also inhibitory to SHP-1 [56] and is being explored as an anti-tumour agent, however this is due to its inhibitory effects on dual specificity protein phosphatase 26 (DUSP 26), which is overexpressed in neuroblastoma, rather than as a result of SHP-1 inhibition [57].