Although this system might appear to fail to take advantage of the increased antigen-dependent proliferation of naive SHP-1null T-cells described by Sathish et al. [37,61], the authors observed increased proliferation of transferred effector T-cells in response to tumour in vivo, reduced apoptosis and improved survival of SHP-1−/− T-cells, and, ultimately improved clearance of leukaemia. This evidence concerns the gene NR0B2 and neoplasm.