CD4 and infection: To investigate whether inclusion of exon7 influences TH17 differentiation, we adenovirally transduced naive CD4+ T cells expressing a signalling-deficient coxsackie adenovirus receptor (CARΔ1) from Malt1−/−R26/CAG-CARΔ1stop-flCd4-Cre mice12, 25 using green fluorescent protein (GFP) as infection marker (Supplementary Fig. 3a).