Chronic CCl4 exposure also decreased the plasma levels of a broad spectrum of DGs and TGs; however, these were similar to those caused by hepatopathy associated with either chronic exposure to ETB, which did not lead to fibrotic changes (Additional file 1: Figure S3), or with acute CCl4 exposure, prior to the onset of the fibrotic changes (Additional file 1: Figure S4). This evidence concerns the gene EDNRB and Decreased liver function.