In von Willebrand disease, mutations in VWF can perturb formation of WPBs and affect the release of VWF and the string formation, leading to excessive bleeding (Michaux et al., 2003; Sadler, 1998; Valentijn and Eikenboom, 2013), thus correct biogenesis of WPBs and storage of VWF is crucial for normal haemostasis. This evidence concerns the gene VWF and Von Willebrand disease.