In contrast to SH3TC2, many demyelinating CMT-associated proteins that are known or predicted to play a role in intracellular membrane trafficking, such as LITAF, MTMR2/MTMR13, NDRG1, FIG4, and DNM2, are widely expressed in different tissues [51], [52], [53], [54], [55] and are also evolutionarily conserved in species that predate the emergence of chordates [56], [57], [58], [59], [60]. Here, SH3TC2 is linked to Charcot-Marie-Tooth disease.