When multivariate logistic regression analysis was performed, the high serum IL-6 levels was the most significant risk factor associated with febrile seizures among studied children (OR: 6.2; 95 % CI: 3.58 –10.57; P = 0.0001), but low serum leptin levels were also significantly associated with febrile seizures (OR: 2.2; 95 % CI: 1.09 –4.78; P = 0.047); Table 3. This evidence concerns the gene LEP and Seizure.