TNF-α, known as an important contributor to the syndrome of cancer cachexia and other chronic inflammatory conditions, diseases in which ferritin levels are frequently altered, and another pro-inflammatory cytokine interleukin-1α (IL-1α) transcriptionally induces the H chain of ferritin, suggesting that pathways related to inflammation and stress can have an impact on ferritin regulation [33]. Here, TNF is linked to cancer.