Multivariate regression analysis stratified by gender and adjusted according to age, body mass index hyperlipidimia and smoking habits as covariates, confirmed the dichotomous age (p = 0.012), hyperlipidemia (p = 0.027) effect of the Mn-SOD Ala16Val polymorphism on CHD severity. The gene discussed is SOD2; the disease is coronary artery disorder.