Subgroup analysis based on the ethnicity suggested that the CDH1 promoter methylation status was significantly increased risks of ovarian cancer in Asian population and Caucasian population (OR = 13.20, 95 % CI = 6.12 - 28.45; OR = 3.84, 95 % CI = 1.52 - 9.74; respectively). The gene discussed is CDH1; the disease is ovarian cancer.