In a multivariable model for controls without RA, both thigh subcutaneous adiposity and IL-18 were related independently to GlycA, and together explained 47 % of the variance in GlycA (P <0.001, Rthigh subcutaneous adiposity = 0.35, RIL-18 = 0.12; Table 3). This evidence concerns the gene IL18 and rheumatoid arthritis.