In a multivariable model for persons with RA, hsCRP, ESR, and thigh muscle density were each related independently to GlycA, and together explained 74 % of the variance in GlycA (P <0.001, RhsCRP = 0.59, RESR = 0.11, Rthigh muscle density = 0.05; Table 3). This evidence concerns the gene ESR1 and rheumatoid arthritis.