SIRT1 and major depressive disorder: The recently published CONVERGE consortium study of Chinese women with recurrent and melancholic MDD identified two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (rs12415800; P=2.53 × 10−10) and the other in an intron of the LHPP gene (rs35936514, P=6.45 × 10−12).21 Neither of these index SNPs were associated with neuroticism within the UK Biobank sample (for rs12415800 β=−0.107, s.e.=0.066, P=0.1036, freq A=0.013; and for rs35936514 β=0.021, s.e.=0.0378, P=0.5832, freq T=0.041).