ADAM22 and autosomal dominant epilepsy with auditory features: Heterozygous mutations in LGI1, which impair LGI1 secretion or binding to its receptors,9 cause autosomal dominant lateral temporal lobe epilepsy (ADLTE; OMIM #600512).10 Although ADAM22 and ADAM23 mutations have not been reported in human diseases, knockout mice for Lgi1,2,11,12Adam22,13 and Adam2314 manifest with lethal seizures during the first postnatal weeks.