The second strongest overlapping signal was on 17q21 (locus no. 2), where the lead CAD SNP (rs46522, p = 2.6 × 10−7) was intragenic in UBE2Z, whereas the lead migraine SNP (rs11079844, p = 3.1 × 10−5) was intergenic between SNF8 and GIP. It is interesting that both lead SNPs are in high LD (r2 > 0.9) with 2 functional variants in GIP: Ser103Gly (rs2291725) and a splice site variant (rs2291726) that is predicted to lead to a prematurely truncated transcript18 (table e-6). Here, UBE2Z is linked to coronary artery disorder.