Six of the overlapping loci have previously been associated with CAD at genome-wide significant levels (loci 1, 2, 4, 7, 8, and 9 of table 2),13,29 and 2 with migraine (loci 1 and 3).12,25 The strongest overlapping region (locus 1) is entirely intragenic in PHACTR1 (which encodes phosphatase and actin regulator 1 protein). Here, PHACTR1 is linked to migraine disorder.