The opposite direction of effect for some of the loci is consistent with a recent GWAS in which the migraine and CAD risk SNP rs9349379 (in PHACTR1) was associated with cervical artery dissection, with effect in the same direction as for migraine but opposite of CAD.23 Two further migraine SNPs showed evidence of association to cervical artery dissection with the same effect direction as for migraine (rs11172113 in LRP1 and rs13208321 in FHL5, the latter identified as locus 3 in the current study) but opposite direction for CAD. The gene discussed is LRP1; the disease is coronary artery disorder.