The second strongest overlapping region (locus 2) is a previously identified risk locus for CAD.13 The lead CAD (rs46522) and migraine variants (rs11079844) are in strong LD (r2 = 0.94), and both are in strong LD (r2 > 0.90) with 2 potentially functional variants in GIP (which encodes gastric inhibitory polypeptide). The gene discussed is GIP; the disease is migraine disorder.