CACNA1C is one of the most widely reproduced risk genes for neuropsychiatric disorders (Heyes et al., 2015), including bipolar disorder (Ferreira et al., 2008; Sklar et al., 2008; Green et al., 2010, 2013; Lee et al., 2011; Psychiatric GWAS Consortium Bipolar Disorder Working Group, 2011; Nurnberger et al., 2014; Ament et al., 2015), schizophrenia (Nyegaard et al., 2010; Hamshere et al., 2013; Ripke et al., 2013; Schizophrenia Working Group of the Psychiatric Genetics Consortium, 2014) , and major depressive disorder (Casamassima et al., 2010; Green et al., 2010). The gene discussed is CACNA1C; the disease is major depressive disorder.