Next, because glucocorticoid receptors have been shown to modulate connectivity and integration of young hippocampal neurons (Fitzsimons et al., 2013), and forebrain-Cav1.2 cKO mice display markedly high levels of anxiety-like behavior that is often associated with elevated levels of stress hormones in animal models, we wondered whether corticosterone levels might also be altered in forebrain-Cav1.2 cKO mice. The gene discussed is CACNA1C; the disease is Anxiety.