CACNA1C and Anxiety: Moreover, even though forebrain-Cav1.2 cKO mice display abnormally high anxiety-like behavior (Lee et al., 2012a), and high corticosterone levels associated with stress are known to reduce hippocampal neurogenesis (Cameron and Gould, 1994; Yu et al., 2010), these mice show normal levels of baseline and stressed brain corticosterone, indicating that their deficit in neurogenesis is not due to secondary effects of abnormally high anxiety.