1997; Mantuano et al. 2003; Romaniello et al. 2010), such as dysarthria, diplopia, hemiplegia, and headache (Jen et al. 2004). Attacks are triggered by emotional stress, exertion, caffeine, or alcohol in similar ways to these disorders and even common migraine. The issue with overlapping symptoms potentially confusing decisions relating to the clinical diagnosis of EA2 and treatment are exemplified in Case 18, in whom we identified a new missense mutation in the ATP1A2 gene (p.Thr570Met), instead of CACNA1A where one was expected to be found. This evidence concerns the gene ATP1A2 and migraine disorder.