2003; Kroiss et al. 2005; Evans et al. 2008; Tea et al. 2014). Two of these trials were conducted at our institution and revealed that a younger birth cohort correlates with a higher BC risk and earlier BC onset in BRCA1 and 2 mutation carriers (Kroiss et al. 2005; Tea et al. 2014). The gene discussed is BRCA1; the disease is breast cancer.