In obesity, macrophages infiltrate adipose tissue and begin to induce proinflammatory cytokines, such as interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNFα), and interleukin-6 (IL-6), which can interfere with insulin signaling in adipocytes [4]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.