This property of therapeutic mAbs is well-established clinically, and a recent study has demonstrated that modification of the Fc region of a CAIX mAb originally identified in a high throughput screen (Xu et al., 2010) increased ADCC in vitro and was effective at targeting orthotopic RCC tumors in an immunocompromised mouse model following allogeneic transplantation of human peripheral blood mononuclear cells (Chang et al., 2015). This evidence concerns the gene CA9 and renal cell carcinoma.