The most common pediatric diseases that can have a component of associated NS in addition to a nephritic picture with histological evidence of FSGS include IgA nephropathy, Hereditary nephritis (Alport’s syndrome), and lupus nephritis The histological picture and immunofluorescence usually reveal the underlying disease, for example, mesangial hypercellularity and mesangial IgA in IgA nephropathy, full-house pattern in lupus nephritis, and thin basement membrane disease with basement membrane abnormalities on EM in Alport’s syndrome (Figure 6). Here, CD79A is linked to Alport syndrome.