The combination of BsmI and ApaI variants showed that AG/TT (OR 6.43, 95 % CI 1.05–39.33, P = 0.08), and GG/GT (OR 8.10, 95 % CI 1.23–53.20, P = 0.06) genotypes provide an increased chance of presenting PSA < 10 ng/mL in PCa patients (Table 6). Here, KLK3 is linked to posterior cortical atrophy.