Although the SNP FokI seems to be functional and the 424 amino acids (aa) VDR variant is somewhat more active than the 427 aa in terms of its transactivation capacity as a transcription factor, no association between this mutation, prostate cancer and BPH has been reported to date (Hayes et al. 2005; Zeng et al. 2014). The gene discussed is VDR; the disease is prostate cancer.