Our results showed that serum TNF-α concentration in SHRs was obviously higher than that in the WKY control rats, treatment with ACRS decreased the serum TNF-α concentration significantly, suggesting that antagonizing fibrosis and myocardial hypertrophy by ACRS may be at least partially correlated with its decreasing of the TNF-α concentration in SHRs. This evidence concerns the gene TNF and cardiac hypertrophy.