This is supported by the finding that in a cell culture model and in a mouse model of muscle disuse, MURF1 inhibition and knockout, respectively, prevented muscle fibre atrophy.93, 94 Pharmacological inhibitors that target specific ubiquitin‐conjugating and deconjugating enzymes are being developed to treat cancer, neurodegenerative disorders, and autoimmune diseases95 but may also be highly relevant for the treatment of COPD‐induced muscle wasting. Here, TRIM63 is linked to chronic obstructive pulmonary disease.