Although exercise induces oxidative stress, which is even accentuated in COPD patients,105 exercise also triggers myogenesis.106 In COPD, this myogenic response to exercise seems intact, although it is specifically impaired in cachectic COPD.40, 98 Exercise‐induced satellite cell activation is mediated by IGF signalling.107 In contrast, MSTN signalling inhibits satellite cell activation.108 Because MSTN expression is increased in COPD, pharmacological inhibition of MSTN might be beneficial to prevent COPD‐induced muscle wasting. This evidence concerns the gene MSTN and chronic obstructive pulmonary disease.