Plant et al. found that the mRNA expression of autophagy‐related genes Beclin‐1 and microtubule‐associated protein 1 light chain 3 alpha (MAP1LC3A, referred to as LC3) is unaltered in the limb muscles of COPD patients compared with controls.57 Limb muscle sequestosome 1 (SQSTM1, referred to as P62) mRNA expression, however, is increased in COPD patients.45 Although the mRNA expression of autophagy‐related genes and the activation of ULK1 may give some insight in the level of autophagy initiation, it does not directly reflect the level of autophagic flux. This evidence concerns the gene MAP1LC3A and chronic obstructive pulmonary disease.