TRIM63 and chronic obstructive pulmonary disease: Furthermore, exercise training may attenuate MURF1 expression, as was observed in the skeletal muscle of chronic heart failure patients.50, 96 In contrast to exercise training, one bout of exercise leads to an increase in MURF1 expression, albeit blunted in COPD,97, 98 while the increase in proteolytic signalling is reduced by branched‐chain amino acid supplementation in a healthy population.97