MEFV and familial Mediterranean fever: The pro-inflammatory feature of the pyrin function and the formation of the pyrin inflammasome has been confirmed in several later studies (Gavrilin et al., 2012; Mankan et al., 2012; Xu et al., 2014), which suggested that FMF-associated mutations are gain-of-function for pyrin and pyrin itself promotes ASC oligomerization and forms a caspase-1-activating complex.