MEFV and familial Mediterranean fever: Recent investigations showing the pyrin inflammasome activation in response to actin modifications (Xu et al., 2014; Kim et al., 2015), together with our results suggesting the excessive activation of neutrophils from FMF patients in ex vivo experiments (Manukyan et al., 2013a,b), warrants further studies of pyrin-cytoskeleton interactions, especially in the case of FMF.