The IL6ST/gp 130 is known to regulate transduction of proinflammatory cytokines, i.e., IL-6 and IL-27 (Silver and Hunter, 2010), which their increased production has been reported in CD patients with chronic colitis (Yamamoto et al., 2000; Lovato et al., 2003). The gene discussed is IL6ST; the disease is Chronic colitis.