INS and Hypercholesterolemia: Certainly, further research is necessary in order to understand whether insulin treatment during pregnancy in women with GDM or coursing without or with supraphysiological hypercholesterolaemia (Leiva et al., 2015) leads to a beneficial or detrimental result on overall angiogenic mechanisms involving or not ERS and/or UPS pathways in the human fetoplacental vasculature.