It is not surprising that an uncontrolled inhibition of NKA can result in severe diseases, e.g., renal failure, hypertension or diabetic neuropathies (Kaplan, 2002) or even death, and that the most specific NKA inhibitor cardiac glycoside ouabain was originally used as an arrow poison (Newman et al., 2008). The gene discussed is TAC1; the disease is diabetic neuropathy.