MAOB and Alzheimer disease: Increased MAO-B activity has been noted in AD in both brain and blood platelets (Adolfsson et al., 1980; Alexopoulos et al., 1987; Sparks et al., 1991), the severe upregulation in the brain mainly being a consequence of a plaque associated neuroinflammatory response by reactive astrocytes (Jossan et al., 1991; Saura et al., 1994).