While loss of α4β2 nAChR can cause memory deficits in AD patients (Paterson and Nordberg, 2000; O’Brien et al., 2007; Kendziorra et al., 2011), a more complex relationship has been noted when evaluating the interaction between α7 nAChR and Aβ in AD (Oddo and Laferla, 2006). Here, CHRNA7 is linked to Alzheimer disease.